Journal · Treatments Explained
Few treatments have risen as fast as polynucleotides. Once a specialist option, they are now one of the most requested injectables in UK clinics, especially for the delicate under-eye area. Here is what they are, how they differ from PDRN and how to choose between products.
Polynucleotides (PN) are chains of nucleotides, the building blocks of DNA, highly purified from fish sources, most commonly salmon or trout. In aesthetic medicine they are injected to support the skin’s own repair and regeneration processes rather than to add volume.
Laboratory and clinical studies suggest polynucleotides may support fibroblast activity, hydration and tissue repair, and they are used to improve skin quality, texture, elasticity and fine lines. As with any treatment, results vary and evidence quality differs between products and indications.
| PN (polynucleotides) | PDRN (polydeoxyribonucleotide) | |
|---|---|---|
| Chain length | Longer chains, higher molecular weight | Shorter fragments, lower molecular weight |
| Texture | More viscous, some scaffold-like support | More fluid |
| History | Widely used in European aesthetics | Long medical history in wound healing, popular in Korea |
| Typical use | Skin quality, under-eye, neck, scarring | Skin quality, redness, post-procedure repair |
In practice the terms are often used loosely. Look at each product’s concentration, chain length and published data rather than the label alone.
Most protocols involve a course of treatments, commonly two to four sessions a few weeks apart, followed by maintenance. Because the aim is biological improvement, results build gradually over weeks rather than appearing immediately. Always follow the manufacturer’s instructions for use.
Our polynucleotides and PDRN range includes many of the brands practitioners ask for, including Plinest, Nucleofill and Rejuran. When choosing, consider:
You will also find hybrid products in skin boosters with PN/PDRN and in biostimulators.
Polynucleotides changed the conversation from “how much product?” to “how healthy is the skin?”
Polynucleotides pair well with skin boosters for hydration, biostimulators for structure and microneedling for texture. Combination protocols are where many clinics see their best results and best patient retention.
Shop polynucleotides and PDRN.
Many are derived from fish DNA, including salmon sperm or trout gonads, then highly purified. Patients with fish allergies should discuss this with their practitioner.
This varies by product, patient and indication. Most protocols include maintenance sessions, often every six to twelve months.
No. They are not designed to add volume. They are used to improve skin quality.
Sources: Manufacturer instructions for use; published clinical reviews of polynucleotides and PDRN in dermatology; Save Face aesthetic trends 2026.
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